Trizipine Long 750 mg tablet number 28

Author Ольга Кияница

2017-05-11

Amount in a package -
Product form Pills
Manufacturer Microhim Ltd. (Ukraine, Rubezhnoye)
Registration certificate UA/12303/01/02
The main medicament Trizipin
morion code 156331

Trizipin Long (TRIZIPIN LONG) user manual

Composition

active ingredient: 1 tablet contains trizipine (3- (2,2,2-trimethylhydrazinium) propionate dihydrate) 500 mg or 750 mg or 1000 mg;
auxiliary substances: ammonium methacrylate copolymer (type B), triethyl citrate, magnesium stearate, silicon colloidal dioxide, talc, ammonium methacrylate copolymer (type A), polyethylene glycol 6000 (macrogol), titanium dioxide (E 171).

Dosage form

Long-acting tablets. Tablets are oval, with a biconvex smooth surface of white or white with a cream-colored hue, with a specific odor, covered with a film membrane.

Pharmacological group

Means that affect the cardiovascular system. The code of automatic telephone exchange С01ЕВ17.

Indications

Trizipin long is used in medical and therapeutic and prophylactic purposes as part of complex therapy of coronary heart disease (angina pectoris, myocardial infarction, chronic heart failure, dyshormonal cardiomyopathy) acute and chronic disorders of blood supply to the brain (cerebral strokes and chronic cerebral circulatory failure); hemophthalmia and hemorrhages in the retina of the eye of various etiologies, thrombosis of the central vein of the retina and its branches, retinopathy of various etiologies (diabetic, hypertonic). Trizipin Long is used with reduced efficiency, physical overload, including in sports practice to accelerate the recovery of athletes; as well as with abstinence syndrome and chronic alcoholism (in combination with specific therapy of alcoholism).

Contraindications

Hypersensitivity to the components of the drug. Organic lesions of the central nervous system. Increased intracranial pressure (with violations of venous outflow, intracranial tumors), pregnancy, children's age.

Dosing and Administration

Assign inside. Doses of Trizipine Long should be selected individually, according to medical indications, the severity of the disease and the anatomical and physiological characteristics of patients.

Cardiovascular diseases or disorders of cerebral circulation.

In the complex therapy to 1.0 g per day for one dose. The course of treatment is 4-6 weeks.

Cardialgia against the background of dyshormonal myocardial dystrophy - inside to 1.0 g per day for one dose. The course of treatment is 12 days.

The acute phase of cerebral circulation disorders is up to 1.0 g per day for one dose. The course of treatment is 4-6 weeks.

Chronic disorders of cerebral circulation - inside to 1.0 g per day for one dose. The course of treatment is 4-6 weeks.Repeated courses (usually 2-3 times a year) are possible after consultation with a doctor.

Vascular pathology and dystrophic diseases of the retina.

Apply the injection dosage form of the drug.

Mental and physical overload, including athletes.

Apply to 2.0 grams per day. The course of treatment is 10-14 days. If necessary, the treatment is repeated after 2-3 weeks.

Athletes are prescribed up to 2.0 grams per day, before training. The duration of the course in the preparatory period is 14-21 days, during the competition - 10-14 days.

Chronic alcoholism.

Up to 2.0 grams per day. The course of treatment is 7-10 days.

Adverse Reactions

From the cardiovascular system: rarely - tachycardia, arrhythmia, changes in blood pressure.

From the hemopoietic system: eosinophilia.

From the side of the central nervous system: rarely - headache, dizziness, psychomotor agitation, paresthesia, tremor, agitation.

From the gastrointestinal tract: rarely - diarrhea, nausea, vomiting, abdominal pain, dyspepsia, metallic taste in the mouth, dry mouth or hypersalivation.

Allergic reactions: rarely reddening and itching of the skin, hives, rashes, angioedema, very rarely anaphylactic shock.

From the respiratory system: shortness of breath, dry cough.

Others: chills, chest pain, weakness, hyperthermia, increased sweating.

Overdose

Sharp changes in blood pressure are possible. Features of application.

Use during pregnancy and lactation

Do not apply.

Children

Not applicable in pediatric practice.

Application features

With caution apply for chronic diseases of the liver and kidneys. For the possible development of a stimulating effect, it is recommended to apply in the morning.

Given the stimulating effect of Trizipin Long on sexual activity and potency, the drug should not be taken before night sleep. Because Trisipin Long inhibits the biosynthesis of carnitine, it should not be administered to patients who suffer from congenital deficiency of carnitine, as well as to patients with thyroid hyperfunction. With caution appoint the drug to patients with severe arterial hypertension or hypotension, since isolated cases of abnormal reactions in such patients.Patients with cirrhosis and severe renal dysfunction take Trizipine long is not recommended. This also applies to patients receiving hemodialysis treatment, as a result of which the carnitine content is significantly reduced.

In the absence of comprehensive data on the safety and efficacy of the use of trimethylhydrazinium propionate in children, Trizipin Long should not be administered to children under 12 years of age. The safety of the drug during pregnancy has not been fully proven. To avoid possible negative effects on the formation of the fetus, Trizipine Long is not prescribed during pregnancy. Since the nature of the drug's excretion into breast milk has not been fully determined, with immediate need for Trisipine treatment, the long-term breastfeeding is stopped for the duration of the drug intake.

To avoid the possible development of a stimulating effect, it is recommended to take Trizipine long in the morning.

The ability to influence the reaction rate when driving vehicles or other mechanisms

During the treatment period, care must be taken when driving vehicles or operating machinery, taking into account the likelihood of side effects that may affect reaction speed and the ability to concentrate attention.

Interaction with other drugs and other interactions

As part of complex therapy, Trisipin Long is used in combination with antianginal drugs, anticoagulants, antiaggregants, antiarrhythmics, cardiac glycosides, diuretics, bronchodilators and other drugs. Trisipin long can enhance the effects of nitroglycerin, nifedipine, beta-adrenoblockers, antihypertensive agents and peripheral vasodilators.

Pharmacological properties

Pharmacodynamics.

Active ingredient Trizipine long-trimethylhydrazinium propionate (meldonium) is a structural analogue of γ-butyrobetaine, a substance that is a precursor of carnitine. The drug, suppressing the activity of γ-butyrobetaine hydroxylase, reduces the biosynthesis of carnitine and the transport of long chain fatty acids in the mitochondria, prevents the accumulation of activated forms of unacidified fatty acids - acylcarnitin A derivatives in cells, thus preventing their adverse effect. Trizipin Long restores the balance of the processes of oxygen delivery and its consumption in cells; prevents transport of ATP, simultaneously activates glycolysis, which occurs without additional consumption of oxygen. As a result of decreasing carnitine concentration, γ-butyrobetaine is intensively synthesized, which has vasodilating properties.

Mechanism of action Trizipin long determines a wide range of its pharmacological effects. It increases the capacity for work, reduces the symptoms of mental and physical overstrain. The drug has a pronounced cardioprotective effect. With heart failure, it improves the contractility of the myocardium, increases tolerance to physical exertion. With stable angina pectoris II and III functional class increases the physical performance of patients and reduces the frequency of angina attacks.

In acute and chronic ischemic impairment of cerebral circulation Trizipin Long improves blood circulation in the ischemic focus, influencing the redistribution of cerebral blood flow in favor of the ischemic site. Trizipin Long is also characterized by a tonic effect on the central nervous system, it eliminates the functional disorders of the somatic and autonomic nervous system, including with abstinence syndrome in patients with chronic alcoholism. The drug also has a positive effect on the dystrophically altered retinal vessels and cellular immunity.

Pharmacokinetics.

Long-acting dosage form Trizipin Long provides a uniform release of the active ingredient for 12-16 hours at a rate of 35-80 mg / h for Trisipin Long tablets of varying strength, regardless of the pH level. The maximum concentration of the active substance in the blood plasma is reached 5-6 hours after taking the drug and gradually decreases during the next 18-20 hours, remaining within the therapeutic range. Metabolism of trimethylhydrazinium propionate is carried out in the liver with the formation of two major metabolites that are excreted by the kidneys. The half-life is 15-17 hours.

Shelf life

3 years. Do not use after the expiration date stated on the package.

Storage conditions

Store at a temperature of no higher than 30 о С in the original packaging. Keep out of the reach of children.

Packaging

For 28 tablets in a polymer jar in a cardboard box.

Category of leave

On prescription.


0.00 avg. rating (0% score) - 0 votes - votes