Olikard retard 60 mg capsule № 20

Author Ольга Кияница

2017-05-11

Amount in a package 20
Product form Bottle
Manufacturer Solvay Pharmaceuticals (Germany)
Registration certificate UA/0453/01/02
The main medicament Olicard
morion code 6277

Olicard retard instructions for use

pharmachologic effect

Peripheral vasodilator with predominant effect on venous vessels. Stimulates the formation of nitric oxide (endothelial relaxing factor) in the vascular endothelium, which causes activation of intracellular guanylate cyclase, resulting in an increase in cGMP (mediator of vasodilation).

Reduces the need for myocardium in oxygen by reducing preload and afterload (reduces the final diastolic volume of the left ventricle and reduces the systolic tension of its walls). Possesses coronary dilatation.
Reduces the flow of blood to the right atrium, helps reduce pressure in a small circle of circulation and regression of symptoms with pulmonary edema. Promotes redistribution of coronary blood flow in the area with reduced blood circulation. Increases tolerance to physical activity in patients with IHD, angina pectoris.
It dilates the vessels of the brain, the dura mater, which can be accompanied by a headache.

The possibility of developing cross-tolerance to other nitrates is not ruled out.

After a break in the application, the sensitivity to the drug is quickly restored.

Indications

- prevention of angina attacks in patients with ischemic heart disease;

- treatment of chronic heart failure (as part of combination therapy).

Dosing regimen

Olikard 40 retard appoint 1 caps. 1 time / day. If necessary, the dose of the drug can be increased to 2 caps / day. In this case, the drug should take 1 caps. 2 times / day. To maintain the therapeutic effect, it is necessary to take the drug a second time not later than 6 hours after the first dose.
Olikard 60 retard appoint 1 caps. 1 time / day.
Treatment begins with a low dose, slowly increasing it to the required level. Duration of treatment is set individually.
Capsules should be taken without chewing and washing down with a sufficient amount of liquid (a glass of water).

Side effect

From the side of the cardiovascular system: "nitrate" headache, marked decrease in blood pressure and / or orthostatic arterial hypotension, which can be accompanied by reflex tachycardia, dizziness, sensation of weakness, short-term hyperemia of the skin; rarely - a bradycardia, a collapse; in some cases - increased symptoms of angina on the background of severe arterial hypotension.

From the side of the digestive system: nausea, vomiting.

Allergic reactions : cutaneous manifestations.

Dermatological reactions: exfoliative dermatitis.

Contraindications

- acute circulatory failure (shock, vascular collapse);

Acute myocardial infarction;

- cardiogenic shock (if by means of intra-aortic counterpulsation or with the help of preparations having a positive inotropic effect, it is not possible to provide a sufficiently high final diastolic pressure in the left ventricle);

- severe arterial hypotension (systolic blood pressure below 90 mm Hg) and hypovolemia;

- simultaneous reception sildenafila;

- children's and adolescence under 18 years (effectiveness not established);

- hypersensitivity to isosorbide-5-mononitrate, the components of the drug and other nitro compounds.

Pregnancy and lactemia

The use of Olikard retard during pregnancy and lactation is possible only if the intended benefit to the mother exceeds the potential risk to the fetus and the baby.

special instructions

With caution should be used in idiopathic hypertrophic subaortal stenosis, constrictive pericarditis and cardiac tamponade, low values of perfusion pressure, incl. with acute myocardial infarction or lack of left ventricle of the heart, aortic and / or mitral stenosis, orthostatic hypotension, diseases accompanied by increased intracranial pressure, severe anemia, angle-closure glaucoma, marked renal and hepatic insufficiency.

Olikard retard is not intended for arresting an acute attack of angina pectoris, acute myocardial infarction.

To prevent the development of tolerance to the drug Olikard retard should avoid its continuous intake in high doses.

Impact on the ability to drive vehicles and manage mechanisms

Because Olikard retard can cause a decrease in the ability to concentrate, patients taking the drug should be careful in dealing with potentially dangerous activities requiring increased attention and speed of psychomotor reactions (especially at the beginning of treatment and with increasing doses).

Overdose

Symptoms: marked decrease in blood pressure, collapse, reflex tachycardia, headache, weakness, dizziness, skin flushing, nausea, vomiting and diarrhea. Large amounts of nitrite ion can cause methaemoglobinemia, cyanosis, dyspnea and tachypnea.
At very high doses of the drug, an increase in intracranial pressure with cerebral symptoms may develop.

In chronic overdose, an elevated level of methemoglobin is detected.

Treatment: gastric lavage. If there is a marked decrease in blood pressure and / or shock, plasma replacement therapy should be performed; in exceptional cases, you can enter intravenously infusion norepinephrine and / or dopamine.

The use of epinephrine (adrenaline) and related compounds is contraindicated.

At methemoglobinemia enter : ascorbic acid - 1 g IV; 1% solution of methylthioninium chloride (methylene blue) - 1-2 mg / kg (up to 50 ml) in / in; conduct oxygen therapy, hemodialysis, blood transfusion.

Drug Interactions

With the simultaneous administration of Olikard retard with antihypertensive drugs, vasodilators, antipsychotics, tricyclic antidepressants, procainamide, quinidine, beta adrenoblockers, calcium channel blockers, dihydroergotamine, sildenafil and ethanol, hypotensive effect may increase.

With the combination of Olikarda retard with amiodarone, propranolol, blockers of slow calcium channels (including verapamil, nifedipine), the antianginal effect may increase.

Under the influence of adrenostimulyatorov, alpha-adrenoblokatorov possible decrease in the antianginal effect of Olicard retard (excessive reduction of blood pressure and, consequently, coronary perfusion).

Olikard retard with simultaneous application reduces the effect of vasoconstrictive drugs.

With the combined use of olikarda retard with m-holinoblokatorami (atropine) increases the likelihood of increased intraocular pressure.

With the simultaneous application of Olikard retard, the concentration of dihydroergotamine in the blood plasma increases.

Barbiturates accelerate metabolism and reduce the concentration of isosorbide-5-mononitrate in blood plasma.

Adsorbents, astringents and enveloping agents reduce the absorption of isosorbide-5-mononitrate in the digestive tract.

Terms and conditions of storage

The product should be stored out of the reach of children at a temperature not exceeding 25 ° C. Shelf life - 3 years.

Conditions of leave from pharmacies

The drug is released by prescription.


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