Author Ольга Кияница


Amount in a package 1
Product form Bottle
Manufacturer PJSC Farmak
Registration certificate
The main medicament
morion code

Corvalol instructions for use


active ingredients: a-bromoisovaleric acid ethyl ester, phenobarbital, mint oil,

1 ml of the solution (26 drops) contains ethyl ester of a-bromizovaleric acid in terms of 100% substance 20 mg, phenobarbital 18.26 mg, mint oil (Mentha oil) 1.42 mg

Excipients: stabilizer, ethanol 96%, purified water.

Dosage form

Oral drops.

Basic physical and chemical properties: transparent colorless liquid with a specific odor.

Pharmacological group

Sleeping pills and sedatives. Barbiturates in combination with other components. The ATX code is N05C B02.

Pharmacological properties


Corvalol ® - a soothing and antispasmodic agent, the effect of which is determined by the components that make up its composition.

Ethyl ester of α-bromizovaleric acid shows a reflex calming and spasmolytic effect due to irritation of predominantly oral and nasopharyngeal receptors, a decrease in reflex excitability in the central parts of the nervous system, an increase in inhibitory phenomena in neurons of the cortex and subcortical structures of the brain, as well as a decrease in activity of the central vasomotor centers and a direct local spasmolytic effect on smooth muscle vessels.

Phenobarbital suppresses the activating effects of the centers of the reticular formation of the middle and medulla oblongata on the cortex of the cerebral hemispheres, thereby reducing the fluxes of stimulating influences on the cerebral cortex and subcortical structures. Reducing the activating effects causes, depending on the dose, calming, tranquilizing or hypnotic effects. Corvalol ® reduces the stimulating effects on the vasomotor centers, coronary and peripheral vessels, reducing overall blood pressure, removing and preventing spasms of blood vessels, especially cardiac vessels.

Oil m ¢ five contains a large amount of essential oils, including about 50% menthol and 4-9% menthol esters. They are able to irritate the "cold" receptors of the oral cavity and reflexively expand primarily the vessels of the heart and brain, removing spasms of smooth muscles, causing a calming and mild choleretic effect. Peppermint oil has antiseptic and antispasmodic effects, the ability to eliminate flatulence. Irritating the receptors of the mucous membrane of the stomach and intestines, enhances the intestinal peristalsis.


When ingested, absorption begins already in the sublingual region, the bioavailability of the constituents is high (approximately 60-80%). Especially fast (after 5-10 minutes), the effect develops when the content in the mouth (sublingual absorption) or reception on a piece of sugar. The action develops in 15-45 minutes and lasts for 3-6 hours. In people who have previously taken barbituric acid preparations, the duration of action is shortened by the accelerated metabolism of phenobarbital in the liver, where barbiturates cause induction of enzymes. In elderly people and in patients with cirrhosis of the liver, the metabolism of Corvalol® is reduced, so their half-life is prolonged, which requires the need to reduce the dose and extend the intervals between doses of the drug.


  • Neuroses with increased irritability;
  • in the complex therapy of hypertension and vegeto-vascular dystonia;
  • indistinctly expressed spasms of the coronary vessels, tachycardia
  • spasms of the intestines due to neurovegetative disorders (as an antispasmodic drug).


  • Hypersensitivity to the components of the drug, bromine;
  • severe violations of the liver and / or kidney function;
  • hepatic porphyria;
  • heart failure
  • medicines containing phenobarbital are contraindicated in severe arterial hypotension, acute myocardial infarction, diabetes mellitus, depression, myasthenia gravis, alcoholism, narcotic and drug dependence, respiratory diseases with dyspnea, obstructive syndrome.

Interaction with other drugs and other interactions

Preparations of the central oppressive type of action enhance the action of Corvalol ®. The effect of the drug is enhanced by the use of drugs valproic acid, alcohol.

Phenobarbital induces liver enzymes and, accordingly, can accelerate the metabolism of certain drugs that are metabolized by liver enzymes (including indirect anticoagulants, cardiac glycosides, antimicrobial, antiviral, antifungal, antiepileptic, anticonvulsant, psychotropic, oral hypoglycemic, hormonal, immunosuppressive, cytostatic, antiarrhythmic, antihypertensive medications).

Phenobarbital enhances the action of analgesics and local anesthetics.

MAO inhibitors prolong the effect of phenobarbital

Rifampicin may reduce the effect of phenobarbital. When used with gold preparations, the risk of kidney damage increases. With prolonged simultaneous use with non-steroidal anti-inflammatory drugs, there is a risk of stomach ulcers and bleeding. The simultaneous use of preparations containing phenobarbital with zidovudine increases the toxicity of both drugs. Increases the toxicity of methotrexate.

Application features

During treatment it is not recommended to engage in activities requiring increased attention, rapid mental and motor reactions.

You should avoid the simultaneous use of alcoholic beverages.

The presence of phenobarbital in the drug may lead to the risk of developing Stevens-Johnson and Lyell syndrome, which is most likely in the first weeks of treatment.

Long-term use of the drug is not recommended because of the risk of developing

drug dependence, the possible accumulation of bromine in the body and the development of bromine poisoning.

In the event that pain in the heart does not go away after taking the drug, you need to see a doctor to exclude acute coronary syndrome. With caution appoint with arterial hypotension, hyperkinesia, hyperthyroidism, hypofunction of the adrenal glands, acute and chronic pain syndrome, acute drug intoxication.

This drug contains 56% vol. % Ethanol (alcohol).

The minimum dose of the drug (15 drops) contains 254 mg of ethanol, which is equivalent to 6.4 ml of beer or 2.7 ml of wine. Harmful to patients with alcoholism. Caution should be exercised when used in patients with liver disease and epileptic patients.

Use during pregnancy or lactation

Do not use during pregnancy and lactation.

The ability to influence the reaction rate when driving vehicles or other mechanisms

Corvalol ® contains phenobarbital and ethanol in its composition, therefore it can cause coordination disruption, speed of psychomotor reactions, drowsiness and dizziness during treatment. In this regard, it is not recommended to engage in activities that require increased attention, including driving and working with machinery.

Dosing and Administration

Corvalol ® is taken inside regardless of food intake 2-3 times a day for 15-30 drops of water or a piece of sugar. If necessary (expressed tachycardia and spasm of the coronary vessels), a single dose can be increased to 40-50 drops.

The duration of the drug is determined by the doctor depending on the clinical effect and tolerability.


Experience with children is not available, so the drug should not be used in pediatric practice.


Overdose is possible with frequent or prolonged use of the drug, which is due to the cumulation of its components.Long-term and constant use can cause dependence, withdrawal syndrome, psychomotor agitation.

Symptoms: depression of breathing, down to stopping it, suppression of the central nervous system, including coma, inhibition of cardiovascular activity, including rhythm disturbances, lowering arterial pressure, up to the collapoid state, nausea, weakness, lower body temperature, decreased diuresis.

Treatment is symptomatic.

Adverse Reactions

Corvalol ®, as a rule, is well tolerated. In some cases, such side effects can occur:

From the digestive system : constipation, a feeling of heaviness in the epigastric region, with prolonged use - a violation of the liver, nausea, vomiting

On the part of the nervous system: weakness, ataxia, disruption of coordination of movements, nystagmus, hallucinations, Parodoxical stimulation, fatigue, delayed reactions, headache, cognitive impairment, confusion, drowsiness, mild dizziness, decreased concentration of attention;

From the side of the immune system: hypersensitivity reactions, including angioedema,

From the skin and mucous membranes: allergic reactions, including skin rash, itching, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis

On the part of the blood system : anemia, thrombocytopenia, agranulocytosis

On the part of the respiratory system: difficulty breathing;

From the cardiovascular system: bradycardia, arterial hypotension

From the musculoskeletal system: with prolonged use of drugs containing phenobarbital, there is a risk of osteogenesis.

With prolonged use, the occurrence of bromide poisoning is possible.

Symptoms : depression of the central nervous system, depression, ataxia, apathy, rhinitis, conjunctivitis, acne or purpura, lacrimation, confusion.

These phenomena occur with a lower dose or discontinuation of the drug.

Shelf life

2 years and 6 months.

Do not use after the expiry date stated on the package

Storage conditions

Store in the original packaging at a temperature not higher than 25 ° C. Keep out of the reach of children.


For 25 ml or 50 ml in a vial. 1 bottle per pack.

Category of leave

A bottle of 25 ml - without a prescription.

A bottle of 50 ml - according to the prescription.

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