Corvalol N capsules №30

Corvalolum N (Corvalolum N) Instructions for use

Composition

active substances: ethyl ester of a-bromoisolecarboxylic acid, menthol solution in menthyl ester of isovalerilic acid, mint oil, hops oil; 1 capsule contains 16.63 mg a-bromosuleric acid ethyl ester, menthol solution in menthol ester of isovalerilic acid 45.74 mg, hop oil 0.17 mg, oil mint 1.18 mg;
auxiliary substances: sunflower oil, saccharalosis, glycerol monostearate, silicon dioxide, colloidal anhydrous;
Capsule shell composition: gelatin, glycerin, liquid maltitol, microcrystalline-guar gum cellulose, potato starch, xylitol, sodium methylparaben (E 219), sodium propylparaben (E 217), flavoring lemon, purified water.

Dosage form.

Capsules are soft.

Basic physical and chemical properties:

soft gelatin capsules of oval shape from light yellow to light brown. The content of the capsules is an oily suspension with a characteristic odor.

Pharmacotherapeutic group.

Sleeping and sedative medications. Combinations of sleeping pills and sedatives, excluding barbiturates. Code ATX N05C X.

Pharmacological properties

Pharmacodynamics. Corvalol N is a calming and antispasmodic remedy, the action of which as a complex drug is determined by its constituents.

The ethyl ester of α-bromovuleric acid has a reflex soothing and antispasmodic effect due to stimulation of the predominantly oral and nasopharyngeal receptors, a decrease in reflex excitability in the central nervous system and an increase in inhibition in the cortical neurons and subcortical structures of the brain, as well as a decrease in the activity of central vasoconducting centers and a direct local spasmolytic effect on the smooth muscle of the vessels.

Validol, or menthol solution in the menthol ester of isovaleriline acid, has a sedative, as well as moderate, coronary expansion effect due to exposure to sensitive nerve mucosal receptors in the oral cavity.

Mint oil contains essential oils, about 50% menthol and 4-9% menthol esters. They are able to irritate the "cold" receptors of the oral cavity and reflexively expand the vessels of the heart and brain, cause a soothing and easy choleretic effect. Peppermint oil has antiseptic, spasmolytic action, the ability to eliminate flatulence. Irritating the receptors of the mucous membrane of the stomach and intestines, it intensifies the intestinal peristalsis.

Hops oil has a reflex vasodilator and antispasmodic action, eliminating the phenomena of flatulence.

Pharmacokinetics. When taken under the tongue, the absorption of the drug begins already from the mucous membrane of the oral cavity. The action develops after 5 minutes and lasts for 3-6 hours.

Clinical characteristics.

Indications

• Neuroses with increased irritability;
• in the complex therapy of arterial hypertension and vegetative vascular dystonia;
• not pronounced spasms of coronary vessels, tachycardia;
• intestinal cramps.

Contraindications

• Hypersensitivity to the components of the drug, bromine;
• pronounced arterial hypotension;
• acute myocardial infarction.

Interaction with other drugs and other types of interactions.

Corvalol N strengthens the sedative effect of psychotropic drugs, opioid analgesics, alcohol and anesthetic agents when they are co-administered.

Possible potentiation of antihypertensive drugs while co-administered with Corvalol N.

Corvalolum N reduces headache due to the intake of nitrates.

Application features

In cases where pain in the area of the heart does not pass after taking the drug, it is necessary to consult a doctor to exclude acute coronary syndrome.

The drug contains less than 1 mmol (23 mg) / sodium dose, i.e. practically free of sodium.

Auxiliary substances that are part of the preparation can cause allergic reactions (possibly delayed).

Use during pregnancy or breastfeeding.

The use of the drug during pregnancy or breastfeeding is possible if, in the opinion of the physician, the expected positive effect for the mother is greater than the potential risk for the fetus / child.

Ability to influence the speed of reaction when driving motor vehicles or other mechanisms.

In the first hours after ingestion side effects (dizziness and drowsiness) are possible. Therefore, when using the product, caution should be given to persons working with complex mechanisms, drivers of vehicles.

Method of administration and dose.

Corvalolum, capsules, are taken under the tongue. The capsule is kept under tongue until it is completely dissolved. To accelerate the effect, you can squeeze the capsule with your teeth.

Accept regardless of meal 2-3 times a day for 1 capsule. If necessary (pronounced tachycardia and spasm of coronary vessels), a single dose can be increased to 2 capsules.

Duration of the drug is determined by the physician depending on the clinical effect and the tolerability of the drug.

Where are you.

There is no experience in children's treatment.

Overdose

It is not recommended long-term use in connection with the possible accumulation of bromine in the body and the development of poisoning with bromine.

Symptoms: headache, nausea, agitation, heart impairment, central nervous system depression, lowering blood pressure.

Treatment: cancellation of the drug and symptomatic treatment.

Adverse reactions

Corvalol N, as a rule, is well tolerated. In some cases, the following side effects can be observed:

• from the nervous system: drowsiness, dizziness, decreased concentration;
• from the side of the digestive tract: abdominal discomfort, mild nausea;
• from the side of the immune system: allergic reactions, including Queinki's edema, urticaria, rash, itching;
• others: short-term arterial hypotension, lacrimation.

Prolonged use of bromine-containing products can lead to poisoning with bromine, which is characterized by symptoms such as central nervous system depression, depressive mood, apathy, confusion, ataxia, purpura, rhinitis, conjunctivitis.These phenomena disappear with a decrease in dose or discontinuation of the drug.

Shelf life

1 year 6 months. Do not apply after the expiry date stated on the packaging.

Storage conditions

Store in original packaging at a temperature not exceeding 25 oC. Keep out of the reach of children.

Packaging

10 capsules in a blister. 1 or 3 blister packs.

Vacation category.

No prescription.